TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

Frequently Asked Questions

Have questions about hereditary angioedema (HAE) and TAKHZYRO? This is the place to find
answers. You can also ask your doctor for more information.

Questions about TAKHZYRO

Questions about HAE

What is TAKHZYRO?

TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older.

It is not known if TAKHZYRO is safe and effective in children under 12 years of age. Want to learn more about TAKHZYRO? Check this page out.

How do you pronounce TAKHZYRO?

Like this: tak-ZYE-roe.

How does TAKHZYRO work?

TAKHZYRO prevents a protein called kallikrein from starting a reaction that leads to HAE attacks. You can watch a video all about it here.

How can I start TAKHZYRO?

To find out if TAKHZYRO is a good option for you, talk to your doctor. You can use this Doctor Discussion Guide to help start the conversation.

What should I tell my healthcare provider before taking TAKHZYRO?

You should tell your healthcare provider about all your medical conditions, including if you are pregnant or planning to become pregnant. It is not known if TAKHZYRO can harm your unborn baby.

You should also tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if TAKHZYRO passes into your breastmilk, so you should talk to your healthcare provider about the best way to feed your baby while using TAKHZYRO.

Can I take other medications with TAKHZYRO?

You should tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.

What are the possible side effects of TAKHZYRO?

TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • fast heartbeat
  • faintness
  • rash
  • hives

The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1–800–FDA–1088.

Can I administer TAKHZYRO myself?

Yes. Once you have been trained by a healthcare provider, you can administer TAKHZYRO yourself. Learn more about administering TAKHZYRO here.

How should I use TAKHZYRO?

  • See the detailed "Instructions for Use" that comes with the Prescribing Information leaflet about the right way to prepare and inject TAKHZYRO
  • Use TAKHZYRO exactly as your healthcare provider tells you to use it
  • TAKHZYRO is given as an injection under your skin (subcutaneous) by you or a caregiver
  • Your healthcare provider should show you or your caregiver how to prepare and inject your dose of TAKHZYRO before you inject yourself for the first time
  • Do not try to inject TAKHZYRO unless you have been trained by your healthcare provider

Does TAKHZYRO come ready to use?

Yes, TAKHZYRO is a ready-to-use solution.

How do I store TAKHZYRO?

TAKHZYRO should be kept in the refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze TAKHZYRO. Make sure you keep TAKHZYRO in the original carton to protect it from light, and do not use it after the expiration date on the vial.

Do not shake TAKHZYRO. Always keep TAKHZYRO and all medicines out of the reach of children.

What is hereditary angioedema (HAE)?

HAE is a rare genetic disorder that can cause sudden episodes of swelling that can be painful and disabling. Learn more about HAE here.

Do I have hereditary angioedema (HAE)?

The only way to find out is to talk with a doctor who knows about HAE. Confirming a diagnosis of HAE usually involves full medical history and a blood test. Learn more about HAE and diagnosis here.

What causes HAE attacks?

Typically, people with HAE are either missing an important protein in their blood called C1-inhibitor, or it doesn’t work the way it should. This can cause another protein, kallikrein, to become overactive. This increase in kallikrein activity results in too much bradykinin, the substance that causes HAE attacks. TAKHZYRO decreases plasma kallikrein activity. See how it works here.

What triggers hereditary angioedema (HAE) attacks?

Some people with HAE have noticed that their attacks can be set off, or triggered, by certain things. Some triggers that have been noted include, repetitive motion like using scissors or physical trauma, like falling off a bicycle or dental surgery. Triggers are different for everyone and some HAE attacks happen without warning. Learn more here.

How is hereditary angioedema (HAE) treated?

There are two main types of HAE treatment: preventive and on-demand. Preventive HAE treatment involves taking medicine routinely to help prevent or reduce the frequency and severity of HAE attacks. On-demand HAE treatment is medicine used to treat the symptoms of an HAE attack. TAKHZYRO is not an on-demand treatment. Talk to your doctor about your options and learn more about treatment types here.

WHAT IS TAKHZYRO?

TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older.

It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

IMPORTANT SAFETY INFORMATION

TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • fast heartbeat
  • faintness
  • rash
  • hives

The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

Please see full Prescribing Information, including information for patients.