TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

How to Take Takhzyro

Reimagine dosing and administration

TAKHZYRO is a subcutaneous (under-the-skin) injection that you give yourself once every
2 weeks. No reconstitution is needed and it comes ready to use.

1

MINUTE
TO SELF-INJECT
for the majority
of patients

Clock icon

EVERY 2 WEEKS

Calendar icon. TAKHZYRO® injection is taken every two weeks

3

CHOICES
FOR INJECTION
Abdomen, either
thigh, or either arm

A body outline with dots on the three TAKHZYRO® injection sites (arm, abdomen, leg).

In clinical studies, the majority of patients self-administered TAKHZYRO over 10 to 60 seconds.

The recommended dose is 300 mg every 2 weeks for people starting on TAKHZYRO. If you have zero attacks for more than 6 months, your doctor may consider prescribing TAKHZYRO 300 mg once every 4 weeks.

It is important to take TAKHZYRO exactly as you have been trained. Do not attempt to take it without first being trained by a healthcare provider.

See Marie's Reimagine Story

View Transcript

MARIE: When I went to the emergency room, I explained to them that I had hereditary angioedema, and I explained the treatment that I was used to receiving. And she said, “I don’t care what you think, lady. You’re gonna have your appendix out tonight.” Hi, I’m Marie, and this is my reimagine story. HAE wasn’t a thing when I grew up. And like many others, I didn’t have a diagnosis until I was an adult. Even though both my grandfather and uncle died from laryngeal swellings, and my father also experienced attacks, doctors didn’t connect our conditions.

MARIE: I had a lot of attacks when I was younger. Everybody thought they were caused by mosquito bites. The first bad attack I had was my throat when I was about 5 years old. My mother and grandmother fed me crushed ice to keep the swelling down, which from what I know now, is not a good idea for treating swells. My sister, who had a similar experience, eventually found a healthcare provider who knew a little bit about HAE. He recommended that our entire family be tested. I was finally diagnosed at the age of 18.

MARIE: I had been relatively happy with my on-demand medication, however, I recently became uneasy with only having a treatment for use when an attack happened. It was our annual Fourth of July party, and like every other year, I had an attack and wound up in bed before it was over. It finally occurred to me that I’d been planning for the attack all along. Every year, I’d look ahead at my schedule for the next few days after the party to see if I had time to deal with an attack. I went to see my doctor and she told me about TAKHZYRO®, a treatment used to prevent HAE attacks in people 12 years of age and older.

MARIE: We went over all the potential risks, such as serious effects, including allergic reaction, as well as more common risks, including injection site reactions, upper respiratory infections, and headaches. Both my doctor and I agreed it was time to start a preventative treatment, and we found that when we were considering the clinical trial results and the safety profile, the benefits of treatment with TAKHZYRO were worth the potential risks for me. I also like the dosing schedule. Taking TAKHZYRO once every two weeks fit well into my lifestyle.

MARIE: On average, I would have three or four attacks a month. Since taking TAKHZYRO, the frequency of my attacks have gone down. These days, I’m enjoying retirement and spending my free time exercising, especially through yoga. It’s a great way to get a good stretch in and practice my breathing. My husband, Al, and I also enjoy entertaining and socializing with our friends and family. I love to go out to dinner and dancing in heels. And recently, after a date night with Al, I was delighted to wake up the next morning to see a blister on my foot instead of a swell.

MARIE: Sometimes it would feel like HAE was beating us pretty bad. Now I feel like my HAE is better managed. If you’re interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

NARRATOR: TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist.

NARRATOR: You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

I like the dosing schedule. Once every 2 weeks fits well into my lifestyle.
Marie Real TAKHZYRO patient

Dosing at a glance

TAKHZYRO
C1-INHIBITOR PREVENTIVE THERAPIES
Dosing schedule
Once every 2 weeks (starting dose)
Once every 3 to 4 days
How much
2 mL
4 to 25 mL*
Administration
Subcutaneous injection
Subcutaneous or intravenous injection/infusion
How supplied
Ready-to-use single dose
Reconstitution required

Table does not imply that one treatment is better than another and does not include all possible HAE treatments. Please see full Prescribing Information for detailed dosage and administration information.
*Based on calculations from approved product Prescribing Information and patient weight assumptions.

TAKHZYRO should be kept in the refrigerator between 36°F and 46°F (2°C and 8° C).

TAKHZYRO Tips

Even if you experience fewer or no attacks during treatment, it is important to keep taking TAKHZYRO as prescribed by your doctor. Remember not to skip a dose or alter your dosing schedule on your own.

Cell phone icon

To help you remember when to take your next dose, set a reminder on your phone or put a note on your calendar. You can also sign up for the TAKHZYRO Text Reminder Program

  • To help you remember when to take your next dose, set a reminder on your phone or put a note on your calendar. You can also sign up for the TAKHZYRO Text Reminder Program
Check mark icon

You should also make sure you have your acute treatment on hand. Remember to periodically check the date to ensure it hasn't expired

  • You should also make sure you have your acute treatment on hand. Remember to periodically check the date to ensure it hasn't expired

How do you remember to take TAKHZYRO?

View Transcript

JENNY: How do I remember to take TAKHZYRO®? I use my calendar app, and I set the event to occur every two weeks.

BOBBI: I use the calendar on my phone, and also my girls remind me when it’s time to give myself the injection.

KYLE: So this is a little bit of a weird one. I have a pet snake, and she is on my schedule with feeding and my medicine. So it’s an every-two-week thing saying, oh, I need to feed her so I need to take my medicine as well.

DYLAN: I generally have a reminder on my phone that will tell me when to take my medication or that it would be every other week, and when I wake up in the morning, I get a simple, little reminder to take my medication. And I take it, and I go about my day.

ANDREA: I remember to to take my TAKHZYRO by listing it on my calendar for every other Saturday between eating my French toast and my bacon.

MARSHA: I got a postcard in the mail that notified me about the text reminding program and it sounded really good, and I signed up right away. And they sent me a text and wanted to know the days of my injection and how often I needed them, and they started coming in right on time.

KEMMI: So I get a text alert the day before so that I make sure that I have my medicine ready and then another text the day of.

KELLY: I set alarms on my phone, and I’ve got it to where it presets. So every time that it’s time for my injection, it automatically goes off, and I have a calendar that I use for work that I see every day that I write it in too.

JUAN: I help my wife remember to take TAKHZYRO by using the calendar app on our phone. We set up a recurring event that repeats itself and reminds us that today is TAKHZYRO day.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO is you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

A body outline with dots on the three TAKHZYRO® injection sites (arm, abdomen, leg).

A healthcare provider will show you the right way to take TAKHZYRO.

See training materials

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Find more information on TAKHZYRO and support for your experience.

Resources to download

WHAT IS TAKHZYRO?

TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older.

It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

IMPORTANT SAFETY INFORMATION

TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • fast heartbeat
  • faintness
  • rash
  • hives

The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

Please see full Prescribing Information, including information for patients.