Freedom from Daily Dosing

TAKHZYRO is an injection taken under the skin. No reconstitution is needed, and it comes ready to use in a prefilled syringe. Explore more information about TAKHZYRO dosing and administration.

≤

MINUTE TO
SELF-INJECT
for most people in the
clinical studies*

WEEKS
BETWEEN
EACH DOSE

CHOICES FOR
INJECTION SITE
stomach, thigh or upper arm

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TERMS AND CONDITIONS

*Most adolescents and adults in the clinical studies self administered TAKHZYRO within 10 to 60 seconds. These injection times are based on vial administration.

TAKHZYRO is a plasma-free, subcutaneous (under-the-skin) injection that you give yourself just once every 2 weeks with a ready-to-use, single-dose, prefilled syringe.

The recommended dose for people 12 years of age and older is 300 mg every 2 weeks. If you experience zero attacks for more than 6 months, your doctor may consider prescribing TAKHZYRO 300 mg every 4 weeks.

Before starting treatment with TAKHZYRO, you will receive training to ensure you know how to administer your therapy. Do not attempt to take TAKHZYRO without first being trained by a healthcare provider.

TAKHZYRO dosing at a glance

Dosing schedule

Once every 2 weeks (starting dose)

How long to administer

One minute or less for most people

How much volume

2 mL

Administration

Subcutaneous injection

How supplied

Ready-to-use, single-dose, prefilled syringe

How stored

Keep refrigerated between 36°F and 46°F (2°C and 8°C)

Please see full Prescribing Information for detailed dosage and administration information.

Give TAKHZYRO 2.5 months to reach steady state if you're an adult or adolescent

With your first dose of TAKHZYRO, the medicine will start to build up in your body. Over the course of your first 6 doses, TAKHZYRO will reach a constant level—also known as "steady state." Once you get there, it's important to keep taking TAKHZYRO exactly as prescribed to help maintain steady state. It takes about 6 doses of TAKHZYRO for the amount of medication to become constant in your body.

Take TAKHZYRO as prescribed by your doctor. Do not miss or skip doses.

STEADY STATE
(about 70 days)

dose 1 dose 2 dose 3 dose 4 dose 5 dose 6
month
2.5 dose 7

Dosing that fits in your child’s life

For children 2 to <6 years of age, 150 mg every

4 weeks

For children 6 to <12 years of age, 150 mg every

2 weeks

TAKHZYRO is a subcutaneous (under-the-skin) injection you or a healthcare professional can administer to your child.

If your child is taking TAKHZYRO every 2 weeks and is well controlled (for example, experiencing zero HAE attacks for more than 6 months), their doctor may consider switching them to every 4 weeks.

Support from Takeda for you and your child

If you’re a parent or caregiver of a child with HAE, starting TAKHZYRO can be a big step for both of you. Takeda is here with support throughout your journey, beginning with injection training.

Once your child is prescribed TAKHZYRO, you will receive training to ensure you know how to administer their therapy

Self-administration is not recommended in children 2 to <12 years of age.

Administer your child’s medicine with the single-dose, ready-to-use, prefilled syringe

Tips for administering your child’s dose

If your child is nervous about receiving their TAKHZYRO injection, try these suggestions. They may help make the process a little easier for everyone involved:

Choose the right environment—find a clean, well-lit space where your child will feel most comfortable

Recommendations from the CDC:

Be honest and calm—explain to your child, in simple terms, what they can expect. Try to remain upbeat and relaxed before, during, and after the injection
Consider distraction—try to draw your child's attention away from the injection. Distractions might include a favorite song, a story, or even a silly face

Need a refresher on your TAKHZYRO injection training?

Explore training materials

View Transcript

Get some tips from people experienced with taking TAKHZYRO.

JACK: Injecting TAKHZYRO has not been a problem for me. For one, I only have to inject it once every two weeks. Plus, it's subcutaneous, which means it's under the skin, not in the vein. That feels manageable for me.

KELLY: Being able to switch up injection sites is a big plus for me personally, that and the fact that I can go two weeks between injections.

SORAYA: After I was trained how to do it, injecting has been manageable for me. I can do it myself, and it takes about a minute. It's an important thing I can do for myself to help reduce the frequency and severity of my HAE attacks.

DENNIS: I was having a hard time prepping the medication the way the OnePath nurse showed me. Luckily, my wife was able to do it, and I just watched her a few times. And now I am proud to say I can do it myself.

ANDREW: The actual injection takes about a minute, and then I'm free from thinking about my next dose for two weeks.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema, HAE, in people 2 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 2 years of age. TAKHZYRO may cause serious side effects including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms, wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, headache, rash, dizziness, diarrhea, and muscle aches. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant and breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

A healthcare provider will show you the right way to use TAKHZYRO.

Explore Training Materials

More support for taking TAKHZYRO

Now that you’re on TAKHZYRO, it’s important to keep taking it as prescribed. Our tips and tools can help you stay on track, so you can stay focused on your treatment goals.

FIND TIPS TO STAY ON TRACK