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TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

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TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

Injection Training Materials

TAKHZYRO comes in a ready-to-use pre-filled syringe and does not require reconstitution. It is a single subcutaneous injection that can be self-administered at home in a minute or less.

Prefilled syringe of TAKHZYRO®.

Injection training materials

Before self-administering TAKHZYRO, you should be trained by a healthcare provider. Caregivers can also receive administration training. These materials contain useful information that reinforce what you will have learned.

The recommended starting dose of TAKHZYRO is 300 mg every 2 weeks for people beginning treatment with TAKHZYRO. If you’ve experienced zero attacks for more than 6 months, your doctor may consider prescribing TAKHZYRO 300 mg every 4 weeks. Your doctor will tell you what dose is right for you.

TAKHZYRO should be kept in the refrigerator between 36° F and 46° F (2° C and 8° C).

Watch how to use the prefilled syringe

View Transcript

Any time you need a reminder, you can watch this video for detailed information about the right way to inject TAKHZYRO with the single-use prefilled syringe. Call your healthcare provider if you have any questions.

For additional safety information, please continue watching until the end of the video. For the full Prescribing Information, including information for patients, please visit TAKHZYRO.com.

Welcome to treatment with TAKHZYRO. Together, you and your healthcare provider have decided that TAKHZYRO is the right preventive option for you.

TAKHZYRO is a single-use, ready-to-use prefilled syringe for injection under the skin (subcutaneous) to be given by your healthcare provider, caregiver, or yourself. Each prefilled syringe contains one 300 mg/2 mL dose. The prefilled syringe is for single use only.

This video will familiarize you with your prefilled syringe and how to use it in 4 key steps. Prepare, Select, Inject, Dispose.

You can give yourself the TAKHZYRO injection, or a caregiver can administer it for you. Before you take TAKHZYRO for the first time, a doctor, pharmacist, or nurse will show you or your caregiver how to properly prepare and inject TAKHZYRO.

Please see the complete Instructions for Use and the Patient Information insert included in your product carton. Contact your healthcare provider if you have any questions.

Before you get started, get to know the parts of your prefilled syringe: the plunger rod, stopper, syringe barrel with medicine, finger grip, and needle cap. Keep the finger grip on at all times. You’ll see and hear these names throughout the video, so it’s good to be familiar with each part.

The prefilled syringe should be stored in the refrigerator between 36 and 46 degrees Fahrenheit until ready for use. Do not freeze it.

Store the prefilled syringe in the original carton to protect it from light. If the syringe has been kept out of the refrigerator, frozen, or not stored in the original carton to protect it from light, throw it away. Do not shake the syringe. Always keep the syringe and all medicines out of reach of children.

When you’re ready, prepare for your injection.

Gather an alcohol swab, a cotton ball or gauze pad, an adhesive bandage, and a sharps disposal container, and place them on a clean, flat surface in a well-lit area.

Next, remove your carton of TAKHZYRO from the refrigerator. Do not use your prefilled syringe if the seal on the carton is open or broken.

Be sure to take the prefilled syringe out of the refrigerator for 15 minutes before injecting. Your medicine is sensitive to warm temperatures. Do not use heat sources such as a microwave or hot water to warm your prefilled syringe.

Open the carton. Holding the syringe barrel, remove the prefilled syringe from the tray. Do not remove the needle cap until you are ready to inject. Take care not to touch or push the plunger rod until you are ready to inject.

While you wait, wash your hands with soap and water, and dry them completely. Also, check the expiration date on the label of your prefilled syringe to ensure it has not passed.

Visually inspect the prefilled syringe for any damage. Do not use the product if the syringe is damaged or cracked. Make sure the medicine is colorless to slightly yellow. Do not administer TAKHZYRO if the medicine is discolored, cloudy, or has flakes or particles in it.

You may see air bubbles in your prefilled syringe. This is normal and will not affect your dose. If you cannot use the prefilled syringe, contact your healthcare provider.

Next, choose where you would like to inject TAKHZYRO, and clean the area.

You can choose a spot on your stomach, thighs, or upper arms. The upper arm is recommended only if a healthcare provider or caregiver is giving you the injection. Do not inject into an area of your body where your skin is irritated, red, bruised, or infected.

The area you choose for injection should be at least 2 inches away from any scars or your belly button. Rotate injection sites to keep your skin healthy. Each new injection should be given at least 1 inch from the last site you used.

Clean your chosen injection site with an alcohol swab and allow it to dry. While holding the middle of the TAKHZYRO prefilled syringe firmly with one hand, gently pull the needle cap straight off with your other hand. Throw the needle cap away. Do not touch the needle or allow the needle to touch anything. You may see air bubbles; this is normal. Do not try to remove the air bubbles.

Now you’re ready to inject TAKHZYRO.

Grip your prefilled syringe in one hand, like a pencil. Avoid touching the needle or pushing on the plunger rod. With your other hand, gently pinch about a 1-inch fold of skin at the cleaned injection site and keep pinching until the injection is complete and the needle is removed.

Inject directly into the fatty layer under the skin (subcutaneous injection). With one quick, dart-like motion, push the needle all the way into your skin at a 45- to 90-degree angle, and make sure to keep the needle in place.

Slowly push the plunger rod all the way down until it stops. Do not withdraw the needle until all of the medicine is injected and the syringe barrel is empty. You will see the stopper at the bottom of the syringe barrel when the injection is complete.

Slowly pull the needle out while holding the syringe at the same angle. Gently release the fold of skin. If needed, press a cotton ball or gauze pad over the injection site, and hold it there for 10 seconds. You may also cover the injection site with an adhesive bandage.

When you’re finished, immediately throw away the used prefilled syringe in a sharps disposal container.

If you have any questions, don’t hesitate to contact your doctor, pharmacist, or nurse—they are there to help.

IMPORTANT SAFETY INFORMATION
TAKHZYRO® (lanadelumab-flyo) may cause serious side effects, including allergic reactions
. Call your healthcare provider or get emergency help right away if you have any of the following symptoms:

  • wheezing
  • difficulty breathing
  • chest tightness
  • fast heartbeat
  • faintness
  • rash
  • hives

The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

WHAT IS TAKHZYRO?

TAKHZYRO (lanadelumab-flyo) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older.

It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

Please see full Prescribing Information, including information for patients, at TAKHZYRO.com.

Image of kelly.
I liked the fact that most people were able to inject within a minute or less.
Kelly Real TAKHZYRO patient

If you are using the vial and syringe

TAKHZYRO® Instructions for Use brochure.

The Instructions For Use brochure provides detailed written instructions for using the TAKHZYRO vial and syringe. Read it to help reinforce what you learned from your healthcare provider.

Download instructions

Descargar instrucciones

Watch how to use the vial and syringe

View Transcript

Any time you need a reminder, you can watch this video for detailed information about the right way to inject TAKHZYRO with the single-use vial and syringe. Call your healthcare provider if you have any questions.

NARRATOR: What is TAKHZYRO®? TAKHZYRO (lanadelumab-flyo) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. Important safety information. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. Please see full Prescribing Information, including information for patients, located at www.takhzyro.com.

SARAH: Hi, my name is Sarah. Together with your doctor, you have determined that TAKHZYRO is an appropriate treatment for you to help prevent HAE attacks.

SARAH: TAKHZYRO is administered as a single subcutaneous injection every two weeks. TAKHZYRO is a ready-to-use solution that does not require reconstitution and is supplied in a single-use glass vial. Today, in this instructions-for-use video, I will be walking you through the administration process for TAKHZYRO. After being trained by a nurse or your healthcare provider, you'll be able to self-administer TAKHZYRO from the comfort of your home. Your caregivers can also be trained on the administration process.

SARAH: In addition, you should always follow specific instructions given by your healthcare provider and contact him or her if you have any questions. It may be helpful to use reminders for your injection dates to help you stay consistent with your treatment. I like to set a reminder notification in my phone, but you can use any tool that's helpful for you, such as a calendar, journal, or planner. When you are ready to administer TAKHZYRO, you will need the vial containing TAKHZYRO ready-to-use solution.

SARAH: TAKHZYRO should be stored in the refrigerator between 36 and 46 degrees Fahrenheit, or 2 and 8 degrees Celsius, until used. Never freeze the vial. Store TAKHZYRO in the original carton to protect the vial from light. Always keep TAKHZYRO and all medicines out of the reach of children. You will also need the following supplies which do not come with the medication: one 18G transfer needle, one 27G, 1/2-inch injection needle, one empty 3 mL syringe.

SARAH: You'll also need alcohol wipes to clean the top of the vial and to clean the injection site, a sharps disposal container to discard all materials after each injection, and TAKHZYRO Instructions For Use. Administering TAKHZYRO can be summarized in six steps. Prepare for your injection. Attach transfer needle to the syringe. Transfer TAKHZYRO into the syringe and switch to the injection needle. Select and prepare an injection site. Inject TAKHZYRO, and throw away the needles and syringe.

SARAH: Gather all supplies, and place them on a clean, well-lighted, flat work surface. To prepare the vial, take it out of the refrigerator 15 minutes before use, and allow it to reach room temperature. Check the expiration date on the box and vial label. Do not use if the expiration date has passed. Check the supplies for damage, and do not use if they appear damaged.

SARAH: Make sure your work area is clean, and wash your hands with soap and water. Do not touch any surface or body part, especially your face, after washing your hands before your TAKHZYRO injection. Remove the vial from the packaging. Do not use the vial if the plastic cap covering is missing. Gently turn the vial upside down three to five times to mix the medicine.

SARAH: Do not shake the vial to avoid foaming. Be sure to look at the medicine in the vial. Do not use if it contains visible particles or has changed color. Normally, the medicine is colorless to slightly yellow. Next, place the vial on a flat surface. Remove the plastic cap from the vial, and clean the rubber stopper with an alcohol wipe and allow it to dry. Do not remove the rubber stopper.

SARAH: To transfer TAKHZYRO from the vial to the syringe, first screw the 18G transfer needle to the 3 mL syringe, keeping the needle cap on. Pull back the plunger to fill the syringe with air equal to the amount of medicine in the vial. This should be equivalent to 2 mL. Hold the syringe by the barrel with one hand, and the transfer needle cap with the other hand.

SARAH: Pull off the needle cap straight away from the syringe and away from your body. Do not pull on the plunger or touch the needle tip. Keep the vial on a flat surface and insert the transfer needle into the center of the rubber stopper. Push the plunger down to inject air into the vial, and hold the plunger down. Then, turn the needle and vial upside down slowly and pull back on the plunger to withdraw the full dose in the vial.

SARAH: To be sure the full dose is withdrawn, it's critical to keep the tip of the needle in the medicine to avoid drawing air into the syringe as you pull the plunger back. Next, remove large air bubbles by gently tapping the syringe barrel until bubbles rise to the top, then slowly push the plunger to allow air to go back into the vial until the medicine reaches the top of the syringe. Repeat these steps until large air bubbles are removed. Check again to make sure you have the right amount of medicine in the syringe.

SARAH: If you don't have enough, pull back on the plunger again while keeping the needle in the medicine to get your full dose. Return the vial to an upright position. Without removing the needle from the vial, unscrew the syringe by holding the needle hub and turning the syringe counterclockwise. Return the syringe to an upright position. You'll need to inject your dose of TAKHZYRO within two hours of drawing it into the syringe.

SARAH: Remember to throw away the 18G transfer needle and the vial in a sharps disposal container. Attach the 27G, 1/2-inch injection needle by screwing it to the syringe. Do not remove the needle cap from the needle when attaching the syringe. TAKHZYRO can be self-administered in your abdomen or thigh. If given by a caregiver, TAKHZYRO may also be injected in the upper arm.

SARAH: Clean the injection site with a new alcohol wipe, and let it dry completely. You can inject your abdomen, thigh, or upper arm. You should use a different injection site each time you inject to keep your skin healthy. When choosing a site, keep in mind that the spot should be at least 2 inches away from any scar or your belly button. Do not choose an area that is bruised, swollen, or painful.

SARAH: When ready, hold the syringe by the barrel with one hand and the injection needle cap with the other hand. Remove the needle cap by pulling it straight away from the syringe and away from your body. Do not pull on the plunger or touch the needle tip or allow it to touch any other surface. Gently pinch about one inch of skin at the cleaned injection site and insert the needle subcutaneously, or under the skin. Be sure to inject under the skin, which is not too shallow (skin layer) or too deep (muscle).

SARAH: Slowly push the plunger to inject all the medicine until none of it remains in the syringe. Release the skin fold and gently remove the needle. Do not recap the needle. Discard the injection needle and syringe in a sharps disposal container. Follow your community guidelines on the right way to dispose of your sharps disposal container.

SARAH: As a reminder, by taking TAKHZYRO every two weeks as prescribed, you'll continue to help prevent HAE attacks. You can set notification reminders to help remember. If you ever have any questions regarding administration, you can call OnePath® to put you in contact with an injection training nurse, or you can always talk to your healthcare provider. Also, OnePath will arrange at any time for a specially trained nurse to take you or a loved one through the TAKHZYRO injection process step-by-step to make sure you are comfortable with administration.

SARAH: If you have any questions, feel free to call your OnePath Patient Support Manager at 1-866-888-0660.

NARRATOR: What is TAKHZYRO? TAKHZYRO (lanadelumab-flyo) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

NARRATOR: Important safety information. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

NARRATOR: These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Please see full Prescribing Information, including information for patients, located at www.takhzyro.com.

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