Patient Stories

JENNY: How do I remember to take TAKHZYRO^®? I use my calendar app, and I set the event to occur every two weeks.

BOBBI: I use the calendar on my phone, and also my girls remind me when it’s time to give myself the injection.

KYLE: So this is a little bit of a weird one. I have a pet snake, and she is on my schedule with feeding and my medicine. So it’s an every-two-week thing saying, oh, I need to feed her so I need to take my medicine as well.

DYLAN: I generally have a reminder on my phone that will tell me when to take my medication or that it would be every other week, and when I wake up in the morning, I get a simple, little reminder to take my medication. And I take it, and I go about my day.

ANDREA: I remember to to take my TAKHZYRO by listing it on my calendar for every other Saturday between eating my French toast and my bacon.

MARSHA: I got a postcard in the mail that notified me about the text reminding program and it sounded really good, and I signed up right away. And they sent me a text and wanted to know the days of my injection and how often I needed them, and they started coming in right on time.

KEMMI: So I get a text alert the day before so that I make sure that I have my medicine ready and then another text the day of.

KELLY: I set alarms on my phone, and I’ve got it to where it presets. So every time that it’s time for my injection, it automatically goes off, and I have a calendar that I use for work that I see every day that I write it in too.

JUAN: I help my wife remember to take TAKHZYRO by using the calendar app on our phone. We set up a recurring event that repeats itself and reminds us that today is TAKHZYRO day.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO is you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

LEXI: I've always loved to travel. I love to take quick weekend trips where I'm gone from Friday to Monday. I love to take long trips where I get to relax and just enjoy wherever I'm at. Traveling with TAKHZYRO^® allows me to do that with more confidence, in having to take my medicine either before I leave for my trip because it was the time to inject and I don't have to inject again for two more weeks.

KEMMI: My patient support manager, with OnePath® sent me a travel kit, and it includes a cold pack to keep my medication cold, and I've traveled with it by air.

KEMMI: I've had no problems going through security. And if I'm just going away for the weekend, it's really easy to take with me.

JACK: For myself, it's great to know that TAKHZYRO is once every two weeks. So, a lot of times when I'm traveling a lot, I can plan around when I need to give myself an injection.

KYLE: Honestly, I really haven't had to travel with TAKHZYRO, because it's an every-two-week administer, and I take it before I even have to travel. It's just how my schedule works, actually.

KYLE: And if I do have to travel with it, my doctor has provided me a travel note saying that I have to have this for medical purposes.

LINDA: I had previously been taking a carry-on on the plane with just medication and had to check a bag. Now, with TAKHZYRO, I have the freedom of packing one dose of medication in one box, maybe two if I'm going to have an extended stay.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older.

NARRATOR: It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

NARRATOR: These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

JENNY: Hello, everyone. I’m Jenny, and this is Bobbi.

BOBBI: We both have HAE, and we also both use TAKHZYRO^®.

JENNY: Mm-hmm. TAKHZYRO is a medication used to prevent attacks of HAE in patients 12 years of age and older.

BOBBI: As you may know, TAKHZYRO is not made from human plasma. This made me wonder: What is it made from?

JENNY: Mm-hmm, right. Me too. So when my doctor prescribed TAKHZYRO for me, we talked about how it was made.

BOBBI: We thought other people might be wondering too. So we’re here to tell you.

JENNY: TAKHZYRO is the only preventive treatment for HAE that’s made using cells in a lab.

BOBBI: This means it does not depend on human plasma donations.

JENNY: Correct. Instead, the cells are multiplied as needed to make TAKHZYRO.

BOBBI: And while the cells originally came from hamster ovaries, no hamsters are used or harmed in the making of TAKHZYRO.

JENNY: A similar process has been used for decades to make medications for many other conditions, including osteoporosis, rheumatoid arthritis, Crohn’s disease, psoriasis, and asthma.

BOBBI: That’s pretty cool, right?

JENNY: I think so.

BOBBI: You can ask your doctor for more information about this if you are curious. In the meantime, here’s some important safety information you should know, too.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

LEXI: I could have a small hand swell on a Monday, and then finally get over that, and by Wednesday or Thursday, my feet may be irritated, or my ankle may have just had a light swell. Hi, I’m Lexi, and this is my reimagine story. I’m a social media manager in Louisville, and I’m also getting my master’s degree. It’s been busy, but I love my job, and I love being in school. I was diagnosed with HAE when I was 7 years old.

LEXI: My father has it, his sister has it, and his father has it, so we were on alert. The first HAE attack I remember was a stomach attack. I was on the couch hugging myself, wondering when it would be over. After that, I started having attacks more frequently. I missed school and had to rest a lot, which was really frustrating, because I wanted to do what the other kids were doing, like playing volleyball. My best friends played, and I was so mad that I couldn’t do it. It sounds silly, but at that age, everything is really serious.

LEXI: Fortunately, when I was older, there were more treatment options available to help me manage my HAE. I went to college, met my boyfriend, D.J., and started a career. We even adopted a dog. As time went by, I felt that I was ready to take more control of my health and treatment decisions. I was interested when I heard about TAKHZYRO^®, a once-every-other-week subcutaneous injection used to prevent HAE attacks in people 12 years of age and older.

LEXI: Before deciding to try another option, my doctor and I talked about every aspect of the treatment, including the potential risks associated with TAKHZYRO, including serious side effects, like allergic reactions, and the more common ones, like injection site reactions, upper respiratory infections, and headaches. We also discussed if it was a good option for me. Remember, not everyone is the same. These days, D.J. and I are on the go a lot. We love taking our dog out and going to concerts and vintage shopping. Basically, we’re huge on experiences, and that means traveling, too, most recently to New York City.

LEXI: Fitness is a big part of my life as well. I love jogging and try to get out as much as I can. Spin classes, too. When I was a kid, I didn’t know what would happen. I hated having HAE. But as treatment options became more available, I felt more positive, and that’s what I would say to others. Be positive. You may have HAE, but HAE does not have you. On average, I would have about one to two attacks per week. Since taking TAKHZYRO, the frequency of my attacks has gone down. If you are interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

MARIE: When I went to the emergency room, I explained to them that I had hereditary angioedema, and I explained the treatment that I was used to receiving. And she said, “I don’t care what you think, lady. You’re gonna have your appendix out tonight.” Hi, I’m Marie, and this is my reimagine story. HAE wasn’t a thing when I grew up. And like many others, I didn’t have a diagnosis until I was an adult. Even though both my grandfather and uncle died from laryngeal swellings, and my father also experienced attacks, doctors didn’t connect our conditions.

MARIE: I had a lot of attacks when I was younger. Everybody thought they were caused by mosquito bites. The first bad attack I had was my throat when I was about 5 years old. My mother and grandmother fed me crushed ice to keep the swelling down, which from what I know now, is not a good idea for treating swells. My sister, who had a similar experience, eventually found a healthcare provider who knew a little bit about HAE. He recommended that our entire family be tested. I was finally diagnosed at the age of 18.

MARIE: I had been relatively happy with my on-demand medication, however, I recently became uneasy with only having a treatment for use when an attack happened. It was our annual Fourth of July party, and like every other year, I had an attack and wound up in bed before it was over. It finally occurred to me that I’d been planning for the attack all along. Every year, I’d look ahead at my schedule for the next few days after the party to see if I had time to deal with an attack. I went to see my doctor and she told me about TAKHZYRO^®, a treatment used to prevent HAE attacks in people 12 years of age and older.

MARIE: We went over all the potential risks, such as serious effects, including allergic reaction, as well as more common risks, including injection site reactions, upper respiratory infections, and headaches. Both my doctor and I agreed it was time to start a preventative treatment, and we found that when we were considering the clinical trial results and the safety profile, the benefits of treatment with TAKHZYRO were worth the potential risks for me. I also like the dosing schedule. Taking TAKHZYRO once every two weeks fit well into my lifestyle.

MARIE: On average, I would have three or four attacks a month. Since taking TAKHZYRO, the frequency of my attacks have gone down. These days, I’m enjoying retirement and spending my free time exercising, especially through yoga. It’s a great way to get a good stretch in and practice my breathing. My husband, Al, and I also enjoy entertaining and socializing with our friends and family. I love to go out to dinner and dancing in heels. And recently, after a date night with Al, I was delighted to wake up the next morning to see a blister on my foot instead of a swell.

MARIE: Sometimes it would feel like HAE was beating us pretty bad. Now I feel like my HAE is better managed. If you’re interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

NARRATOR: TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist.

NARRATOR: You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

SEBASTIAN: A bad month for me would be just constantly swollen. Something would be always swollen. A good month would be probably going a full week with maybe one attack. Yeah, that’d be a good month. Hi, I’m Sebastian, and this is my reimagine story. I grew up like most kids with HAE. Having odd swellings here and there. I remember going to school wearing slippers because my feet were too swollen for my shoes to fit.

SEBASTIAN: Doctors always dismissed my swellings as consequences of roughhousing. But my life changed the day I had a laryngeal, or throat, attack. I was studying for a finals exam when I felt my airway constricting. I quickly realized my throat was swelling. My mom picked me up at school and sped her way to the hospital. By the time we arrived, my throat was swollen shut, and I was intubated for two days. My condition went from being a nuisance to life-threatening in 3 hours. Thankfully, an HAE specialist happened to be visiting the hospital while I was there and made my diagnosis.

SEBASTIAN: As time went on, my HAE worsened. Seven to 10 attacks a month became the norm. Eventually, I started taking on-demand treatment, but I was still living my life around attacks. What was even more upsetting was that my children began to realize I was sick. I knew it was time to do more than just treating attacks reactively. I pride myself in being an involved patient, and given my background in science, I’ve always had an interest in learning how to prevent attacks.

SEBASTIAN: That’s what led me to ask my doctor about TAKHZYRO^®, a once-every-two-week subcutaneous injection used to prevent HAE attacks in people 12 years of age and older. My doctor and I discussed the potential risks, such as serious side effects, including allergic reactions, as well as more common risks, including injection site reactions, upper respiratory infections, and headaches. After considering the benefits and potential risks, we moved forward with TAKHZYRO. Since starting, the frequency and severity of my attacks has lessened, and my on-demand treatment has gone unused for a while.

SEBASTIAN: I’ve even gone months without an attack. But these are my experiences, and not everyone will be the same. I have to be active and available for my 3 little ones. It means the world to me to be able to play catch or work in the garden with them. But my favorite way to spend time with my family is going to the beach. I hope my reimagine story will help others, especially my family members with HAE. I want them to know HAE may be tough, but so are you. If you are interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider, or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

CAMILA: I am a school psychologist here in Texas because I love kids and teenagers. So having that opportunity of sharing or impacting positively parents and teachers and students all together was like the top of everything for me. Hi, I am Camila, and this is my reimagine story. I am from Puerto Rico, but now I live in Texas where I am a school psychologist.

CAMILA: Many people in my family have HAE: my mother, brother, aunt, uncle, cousins, and many more. I remember my first attack so clearly. I was about 5 years old, and I woke up with something wrong with my right hand. I ran to my mother and asked her what was happening. She just started crying. That was it. My first HAE attack. When I was 10, I was officially diagnosed.

CAMILA: My swells got worse as I got older, but I was determined not to let my HAE hold me back. I went to university and tried to participate as much as I could, both in and out of class. When I had my first throat swell, my doctor and I decided it was time to start on-demand treatment. Having it helped me feel more prepared to manage my HAE, which had become quite unpredictable.

CAMILA: Even so, I accomplished a lot. I studied abroad, graduated, and even got married to my biggest supporter, my husband, Jorge. After a while, we decided to relocate to Texas, which was a big change, but an exciting one. However, I was having more frequent throat swells. So I began to discuss treatment options with my doctor that could help me potentially prevent future attacks.

CAMILA: He told me that one option might be TAKHZYRO^®, a once-every-two-week subcutaneous injection used to prevent HAE attacks in people 12 years of age and older. He also told me that patients in the trial experienced fewer and less severe attacks. We made sure to discuss the potential risks, such as serious side effects, including allergic reactions, as well as more common side effects, including injection site reactions, upper respiratory infections, and headaches.

CAMILA: I was on board with all the benefits and the risks, so he signed me up. Everyone is different, though. On average, I was having three to four attacks per month before starting treatment. I’ve been on TAKHZYRO for quite a while now, and I can happily say that it has helped me reduce the frequency and severity of my attacks. I’ve even gone a month without an attack. This is my experience, and not everyone will be the same. My husband and I have really been enjoying all that Texas has to offer.

CAMILA: We are always trying new places to eat, and we love to go dancing. That’s how we first met years ago. We also love to travel and are always looking for new places to visit and explore. I am optimistic for the future, both for me and for my family, and I want to share that optimism with other people who have HAE. Keep your head held high, and have faith that things can get better. If you’re interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

NARRATOR: These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

CAMILA: Soy psicóloga escolar y trabajo aquí, en Texas porque me encantan los niños y adolescentes, así que tener esa oportunidad de compartir con los padres, profesores y estudiantes todos juntos y de generar un impacto positivo en ellos, para mí significó llegar a la cima. Hola, soy Camila y esta es mi historia reimagine. Soy de Puerto Rico pero ahora vivo en Texas donde soy psicóloga escolar.

CAMILA: Muchos de mis familiares tienen angioedema hereditario, incluyendo mi madre, mi hermano, mi tía, mis tíos y otros. Me acuerdo muy bien de mi primer ataque. Tenía unos cinco años y me desperté con un problema en mi mano derecha. Corrí a buscar a mi madre y le pregunté qué estaba pasando. Ella simplemente se puso a llorar. Así fue mi primer ataque de angioedema hereditario. Cuando tenía unos 10 años me lo diagnosticaron oficialmente.

CAMILA: Las inflamaciones fueron empeorando a medida que crecía. Pero estaba decidida a impedir que mi AEH se interpusiera en mi camino. Fui a la universidad e intenté participar lo máximo posible dentro y fuera de clase. Cuando tuve la primer inflamación de la garganta junto con mi médico decidimos que era hora de empezar un tratamiento a demanda. Eso me ayudó a sentirme más preparada para controlar mi angioedema que se había tornado bastante impredecible.

CAMILA: A pesar de ello logré muchas cosas. Estudié en el extranjero, me gradué y me casé con mi mayor sostén, mi esposo Jorge. Después de un tiempo decidimos mudarnos a Texas, lo cual fue un cambio muy grande pero a la vez muy emocionante. Sin embargo, empecé a tener inflamaciones de la garganta con más frecuencia. Así que empecé a estudiar con mi médico opciones de tratamiento que posiblemente me pudieran ayudar a prevenir futuros ataques.

CAMILA: Él me dijo que tenía una de las opciones que era TAKHZYRO, una inyección subcutánea que se aplica una vez cada dos semanas para prevenir los ataques de angioedema hereditario en personas mayores de 12 años. También me dijo que los pacientes del ensayo tuvieron menos ataques y de menor intensidad.

CAMILA: Hablamos de los riesgos potenciales como los efectos secundarios graves que incluyen reacciones alérgicas y los efectos secundarios más comunes que incluyen reacciones en el lugar de la inyección, infecciones de las vías respiratorias superiores y dolor de cabeza. Estuve de acuerdo con todos los beneficios y riesgos así que iniciamos el tratamiento.

CAMILA: Pero recuerda que todas las personas son diferentes. Antes de empezar el tratamiento solía tener un promedio de tres a cuatro ataques por semana. Ya llevo bastante tiempo con TAKHZYRO^® y felizmente puedo decir que me ha ayudado a reducir la frecuencia y la gravedad de mis ataques. Esta ha sido a mí experiencia y no va a ser igual para todos.

CAMILA: Mi esposo y yo hemos estado disfrutando realmente de todo lo que ofrece Texas. Siempre vamos a comer a lugares nuevos y nos encanta ir a bailar. Así fue cómo nos conocimos hace muchos años. También nos encanta viajar y siempre estamos buscando lugares nuevos para conocer y explorar. Veo el futuro con optimismo, tanto para mí como para mi familia. Y quiero compartir ese optimismo con otras personas que tengan angioedema hereditario. Así que mantengan su cabeza bien en alto y confíen en que las cosas pueden mejorar.

CAMILA: Si te interesa obtener más información sobre cómo reimaginar tu vida con angioedema hereditario consulta a tu proveedor de atención médica para ver si TAKHZYRO es adecuado para ti.

NARRATOR: TAKHZYRO, lanadelumab, es un medicamento de venta con receta que se utiliza para prevenir los ataques de angioedema hereditario, AEH, en personas de 12 años de edad y mayores.

NARRATOR: Se desconoce si TAKHZYRO es seguro y eficaz en niños menores de 12 años. TAKHZYRO puede provocar efectos secundarios graves que incluyen reacciones alérgicas. Llame a su proveedor de atención médica o busque ayuda de emergencia de inmediato si tiene alguno de los siguientes síntomas: sibilancia, dificultad para respirar, opresión en el pecho, ritmo cardíaco acelerado, desmayos, sarpullido, urticaria.

NARRATOR: Los efectos secundarios más frecuentes observados con TAKHZYRO fueron reacciones en el lugar de la inyección, dolor, enrojecimiento y moretones, infección en las vías respiratorias superiores y dolor de cabeza. Estos no son todos los posibles efectos secundarios de TAKHZYRO. Para obtener más información pregunte a su proveedor de atención médica o su farmacéutico.

NARRATOR: Puede informar de los efectos secundarios a la Administración de Alimentos y Medicamentos, FDA, llamando al 1-800-FDA-1088. TAKHZYRO no ha sido estudiado en mujeres embarazadas o en período de lactancia. Hable con su proveedor de atención médica acerca del riesgo de recibir TAKHZYRO si usted está embarazada, planea quedar embarazada, está amamantando o tiene intención de amamantar.

NARRATOR: Hable con su proveedor de atención médica sobre TAKHZYRO. El único tratamiento preventivo para el AEH que se administra como una inyección subcutánea solo una vez cada dos semanas.

BOB: Hi, my name is Bob. And this is My Reimagine Vlog.

BOB: Hello. My name is Bob, and I've been taking TAKHZYRO for more than 2 years. For me, I've always been about pushing myself to get the most out of life. When I was 19, I joined the Marines, and being in the Marines was all about pushing yourself to perform at your peak. However, there came a point where I couldn't push any further. I was suffering from abdominal attacks, and I didn't know why.

BOB: Nine years into my career as a Marine, I found out that my sister was diagnosed with hereditary angioedema, or HAE. Knowing that, I also got tested and found out that I have HAE as well. The good news was that I finally found out that there was a reason why my body was experiencing all these attacks. But the bad news? After my diagnosis, the career that I was building was suddenly over.

BOB: Where can I push myself further? I don't think I could have pushed myself to become who I am now if I was still in the Marines. It was a blessing in disguise. Since I was no longer enlisted, I had the chance to go on a blind date. And now, 25 years later, that blind date has resulted in having a beautiful wife and 2 children.

BOB: I tried to manage my HAE attacks throughout the years, but my attacks kept coming, sometimes without rhyme or reason. Whenever I was stressed, I would get attacks. Whenever I was just stressed about stress, I would get attacks. HAE was getting the best of me, and I wasn't satisfied with my HAE management plan. Sometimes, my abdominal attacks were crippling and required visits to the ER. I remember one year when I had to go to the ER 6 times. Every time I went in, I would have to re-explain my condition to whoever was on duty while I was in mid-attack. I was being labeled as someone coming in for pain medication.

BOB: Eventually, in September of 2018, my doctor told me about TAKHZYRO. It's a subcutaneous injection that you take just once every 2 weeks to prevent HAE attacks in people 12 years of age and older. He was very clear from the beginning about the clinical trial results, and he said that there was a real possibility that TAKHZYRO could help decrease the frequency and severity of my attacks. We also discussed the potential risks, such as serious side effects, including allergic reactions as well as more common side effects, including injection site reactions, upper respiratory infections, and headaches. My doctor told me to call or get emergency help right away if I experienced any of the following symptoms from an allergic reaction, including wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, or hives.

BOB: What was interesting for me is what my doctor told me about how TAKHZYRO performed in clinical studies. Some patients taking TAKHZYRO 300 milligrams once every 2 weeks experienced on average an 87% reduction in attacks at 6.5 months versus those who took the placebo. Not only that, but TAKHZYRO helped patients reduce moderate or severe attacks, as well as attacks that required acute treatments.

BOB: I've experienced this in real life, though I still keep my acute treatment handy. Some patients in the clinical study also reached zero attacks for periods of time. Prior to using a preventive treatment, I was experiencing 2 to 3 attacks per month. Now with TAKHZYRO, I've gone up to 12 months without an HAE attack. These are my experiences, and I realize every patient's experience is different. So talk to your doctor about TAKHZYRO and if it may be appropriate for you.

BOB: Lately, I've enjoyed playing golf with my wife and daughter. We're practicing our putting wherever we can, just enjoying ourselves, slowly improving our skills at the game. One thing I've always wanted to do is restore an old car. I finally had an opportunity to do that this past year. My friend and I took a vintage 1970s car and turned something old new again, from how it used to run to how it runs now. We've reimagined what was possible for that car, giving it a second opportunity.

BOB: My experience with TAKHZYRO has given me the possibility of fewer attacks. If you're interested in learning more about reimagining your life with HAE, talk to your healthcare provider to see if TAKHZYRO is right for you.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every 2 weeks.

DYLAN: Hi. My name is Dylan, and this is My Reimagine Vlog.

DYLAN: Hello. My name is Dylan, and I've been taking TAKHZYRO for more than 2 years. I've been a gamer for as long as I can remember. I had a controller in my hands the minute I turned 7. I've even competed professionally, taking my love for video games and testing my skills against players around the world. When I was diagnosed with hereditary angioedema, or HAE, at age 13, I knew I had some challenges ahead of me, and they turned out to be greater than I expected. I couldn't play sports in high school, because even a minor injury would send me to the hospital. Just running track one day made my feet swell so much that I had to cut myself out of my own shoes. Because of my abdominal attacks, I would spend nights on the bathroom floor. I missed a lot of school.

DYLAN: A "game over" screen doesn't discourage me, and I don't let my HAE get me down either. When I stay on track with TAKHZYRO, a once-every-2-weeks subcutaneous injection used to prevent HAE attacks in people 12 years of age and older, I'm able to better manage my HAE.

DYLAN: Here are my 5 strategies to staying on track with TAKHZYRO. Level 1: think ahead, be prepared. The first level to staying on track is to think ahead. I make sure that I have my medication in the fridge, and when it's time for me to inject, I take it out to ensure it's at the proper temperature. When I was a professional gamer, I worked with members of a team to accomplish certain goals. Same thing happened when I was prescribed TAKHZYRO. The first time I took TAKHZYRO, I had a nurse come over to my house, and she showed me how to inject the medication.

DYLAN: Takeda offers a lot of resources for when you get started, including a welcome kit with instructions for use, an adherence brochure, more information about HAE, but also other resources throughout your treatment, like a journey journal, to keep you on track with your treatment goals. Takeda even offers a text reminder program to help you remember when to take your next dose. You can learn more about these resources on TAKHZYRO.com, or talk to your doctor about what else is out there.

DYLAN: Level 2: stay informed and set your expectations. Before I start a new game, I like to see what kind of game it is. That way, I can set some expectations for myself. I took the same approach with TAKHZYRO. I had a conversation with my doctor. My doctor and I talked specifically about the goals and expectations for my treatment journey. He told me about TAKHZYRO, including the clinical studies, and what patients experienced, but he said everyone's experience differs. We started by writing a list of questions, and set goals based on the responses. Was it possible for me to use my acute medication less frequently? When would I start experiencing less severe attacks? When would I start expecting less frequent swells?

DYLAN: We also discussed the potential risks, such as serious side effects, including allergic reactions, as well as more common side effects, including injection site reactions, upper respiratory infections, and headaches. I was educated about the symptoms of an allergic reaction, and my doctors told me to call or get emergency help right away if I experienced any of the following: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, or hives. I feel it's important to set your expectations at the start of your treatment journey with your doctor.

DYLAN: Level 3: maintain perspective and keep looking forward. One of my favorite types of games are first-person games, where you control the character, and see the world from their perspective. After I got diagnosed with HAE, I had to adopt a new perspective. Was it tough to hear at first? Absolutely. Is it the worst thing in the world? Absolutely not. I think back to when my doctor said I had to treat this my whole life, and I thought, “This sucks, it's terrible, and this is such a drag.” However, when you begin treatment with TAKHZYRO, you realize that you have to inject once every 2 weeks. After learning how to inject from my doctor, preparing and taking TAKHZYRO once every 2 weeks, it takes about 20 minutes out of my day. Just 2 or 3 times out of a month to help with my HAE attacks is something I can personally live with.

DYLAN: Level 4: don't be scared of change. Sometimes, when I'm playing through a tough spot in a game, if I can be brave and move forward, new opportunities will present themselves. I took the bold step of starting TAKHZYRO, and staying on track, and it's helped decrease the frequency and severity of my attacks. Take it from me. I did not want to start TAKHZYRO – at first, because I was afraid of change. Since starting TAKHZYRO, I've experienced less frequent HAE attacks, and have gone up to 6 months without an attack. I still make sure to keep my acute treatment with me at all times. I know this may not be the same experience for every patient. Also, talking to my doctor about what to expect has helped me be less scared. Now, I live with my girlfriend, and we have a dog. I want to pursue a career in medicine. There's a whole list of things I want to do. If I had continued to be scared of living life, or scared to even start TAKHZYRO, I wouldn't have known that it was possible to have less frequent attacks, or to be attack-free for periods of time.

DYLAN: Level 5: open up, ask for help. Sometimes, when I'm playing online, I'll be in a tough situation, but I know my teammates have my back. I call on them for support, and they're there for me. That's the same way with my HAE. HAE has put me in tough situations plenty of times, and it can be challenging. But I'm lucky to have people who support me, whether it's my girlfriend, or my sister, or my mom, and I'm not afraid to ask for their help. In a way, they're part of my HAE team. They give me the support I need to stay on track. It's not just TAKHZYRO they help me with, but also making sure I'm doing okay in general. Staying positive, and maintaining a good attitude, has definitely helped me with my HAE. My health is as much my physical condition, as my mental one.

DYLAN: Since starting TAKHZYRO, over 2 years ago, I look back over the years. I see the progress I've made with my HAE. I'm surprised by how far I've come. Through my experiences with TAKHZYRO, I know I have more control of managing my HAE attacks, and I'm ready to start the next level.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every 2 weeks.

JACK: Hi, my name is Jack, and this is My Reimagine Vlog.

JACK: Hello. My name is Jack, and I've been taking TAKHZYRO for more than 2 years. Hereditary angioedema, or HAE, has been a large part of my family's life. Thirteen members of my immediate and extended family had been diagnosed with HAE. Because growing up I knew and cared about so many people with this rare disease, it inspired me to want to take care of others. I was actually diagnosed with HAE at 13, but I didn't have any severe symptoms until much later in life. Some of my family members were so much worse off than I was and I found myself putting to the side that I had HAE as well. I tried to help out as much as any kid could – I’d go to the hospital with my mom, and I'd sit with her while the doctors tried to find a way to manage her pain. From that point on, I made it one of my primary goals in life to pursue a medical career in which I could help other patients. But achieving that was a challenge, as my goals and expectations changed and evolved along the way.

JACK: Fortunately, or unfortunately, my HAE didn't become apparent until I was in nursing school. I started to get swells, and it seemed that stress started to trigger my HAE. The attacks came every few months at first, but then they progressed to every other month. Eventually, I was experiencing attacks every month. After graduation, I got a job as a pediatric oncology nurse, but at this point in my life, my attacks were becoming more frequent and more severe. I wasn't sure how I was going to keep my attacks under control, and it was hard to stay focused at my job. It got to the point where I missed so much work that I was asked to step down from my position.

JACK: I use this time to get really involved with the HAE community. I did some advocacy work. I was mentoring young children with HAE. The more I was involved in the community, the more I learned about HAE and about the treatment options available to us patients. I wasn't interested in trying any preventive medications at the time, but as each year passed, I realized my attacks were becoming more frequent and more severe, and it became clear that I needed to take a closer look at preventive therapies that might be able to help. I wanted a treatment that could reduce the amount of swells I was having. I think fate intervened when I learned about TAKHZYRO during one of my regular doctor's visits. A nurse told us that TAKHZYRO, a once-every-2-weeks subcutaneous injection used to prevent HAE attacks in people 12 years of age and older, had been approved.

JACK: Right then and there, my doctor and I talked about it. We also discussed what to expect and set goals to manage my HAE. Reducing my attack frequency was the primary goal–from having swells every week to less frequently. We also discussed the potential risks such as serious side effects, including allergic reactions, as well as more common side effects, including injection site reactions, upper respiratory infections, and headaches. As far as allergic reactions, my doctor told me to call or get emergency help right away if I experienced any of the following: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, or hives.

JACK: Since starting TAKHZYRO, the frequency and severity of my attacks have decreased. I was accustomed to multiple attacks a week. After starting TAKHZYRO, I've gone a month or two without an attack. I even had a span as long as 6 months when I had zero attacks. And if I do experience an attack, it's usually less severe than before. This is just my experience with TAKHZYRO, and it may not be the same for everyone. 2020 was one of the most stressful years of my life, and like I said earlier, stress is one of my triggers. I built a new house, so my wife and I had to deal with the stress of moving. On top of that, being a nurse during the COVID-19 pandemic has not been easy, to say the least. With all of this happening, I'm glad I had a management plan for my HAE.

JACK: These days, my wife and I are discussing a new goal: starting a family. We're ready to see how we can fill our new place with more joy. And I've been spending my free time exercising. I feel like it's a great way for me to get back into shape, and it helps that we encourage each other to stay fit and follow our workout goals.

JACK: When I was first managing my HAE, all I wanted was to simply reduce the amount of swells from weekly to maybe once a month. After that, the goal was to not go to the hospital as often. Setting goals and expectations is very important. I did it for myself when it came to my career, and I did it for my HAE management plan. I encourage you to talk to your doctor about your individual HAE goals and expectations. This journey has taken me through many ups and downs, and things have evolved along the way. Now I feel my HAE is better managed. I know one goal I can continue to work closely on with my doctor: reimagining life with HAE.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every 2 weeks.

JENNY: Hi, my name is Jenny and this is My Reimagine Vlog. David, are you ready?

DAVID: Yeah.

JENNY: For some spinning?

DAVID: Oh, yeah.

JENNY: Hello, my name is Jenny, and I've been taking TAKHZYRO for more than 2 years. However, I don't think I would have made it this far if not for my caregiver, partner, and husband Juan. It's certainly been a long journey with hereditary angioedema, or HAE, but I've had him with me for a large part of it. He’s seen me when my attacks are so bad that I have to stay in bed and move as little as possible. When I just have to sleep it off and I'm out of commission for days.

JUAN: How did this relationship start? Jenny and I met in Spain where we were college students. Jenny was studying abroad, and she asked me out on our first date.

JENNY: True story. Juan is from Spain and I asked him out for not like a date, date. It was a, "Hey, I'm here studying Spanish. You clearly speak English, so let's do an Intercambio." So it was a total language-geek first date.

JUAN: All I remember was that a cute girl just start asking me out. "Yep, I'll be there." We had lived the long-distance relationship for so many years before we got married. Got married in Spain, got a teeny tiny little apartment, maybe like half an hour away from the Mediterranean, dog, life, you know. But we did want to start a family. So, you know, did a balance, what should we do? So we decided, packed it all up. And here we are a few years later. I mean, we exchanged a little house right away from the Mediterranean to living in New England winters. But I can't say that's too bad of trade.

JENNY: Oh, so sweet.

JENNY: Despite being on a preventive medication already, when I heard about Takeda's preventive treatment TAKHZYRO, a once-every-2-weeks subcutaneous injection used to prevent HAE attacks in people 12 years of age and older, I used this as an opportunity to reach out to my doctor and discuss my HAE management plan.

JENNY: We both took a hard look at the clinical trial data, and we thought it might offer me a chance to experience less severe attacks compared to before being on preventive medication. We discussed the potential risks associated with TAKHZYRO. And my doctor went through the serious side effects, including allergic reactions, as well as more common side effects, including injection site reactions, upper respiratory infections, and headaches. We discussed the symptoms of an allergic reaction. And my doctor told me to call or get emergency help right away if I experienced any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, or hives.

JENNY: After discussing everything at length, I felt comfortable moving forward with TAKHZYRO as my preventive medication. When I started TAKHZYRO, it wasn't exactly smooth sailing. There was a transition period for a few months when I was still getting frequent swells, and I was questioning if TAKHZYRO was right for me. I had to stay home during that time, and Juan would take off work to take care of the boys. Whenever I got an abdominal attack, I would be physically drained. I felt like a battery that was at 0%. But I pushed through with rest, self-care, and by asking for help. It's important to have help. You should not be afraid to ask for it when you need it.

JUAN: And I reminded Jenny that she made this choice carefully with her doctor and I and to stay strong. One consideration that was important to Jenny when she started TAKHZYRO is that it is taken every 2 weeks and that the injection only takes up a small part of her day. I would encourage anyone who is beginning treatment with TAKHZYRO to talk to their doctor about what to expect when they first start and how long it will take for TAKHZYRO to get to a constant level in the body. Seeing Jenny in pain was not easy. And I knew I had to stay strong for our family, but I'm really glad she stuck with it.

JENNY: I continued to take TAKHZYRO, and now, more than 2 years later, my attack frequency and severity have decreased. I still get abdominal attacks once in a while, but I have my acute treatment with me at all times, so I'm prepared. But these are my experiences, and not everyone's experiences with TAKHZYRO will be the same.

JENNY: Knowing that HAE is a genetic condition, we got our sons tested as early as possible. David, our oldest, tested negative, but Sebastian tested positive for HAE in September 2019. Thoughts of guilt flooded my mind after I received that dreadful call. I cried, and I cried a lot. I had to pick up the boys from daycare, and on the drive there, I managed to call Juan while he was at work. The words barely made their way out of my mouth, but they eventually did: "Sebastian has HAE." A long pause followed. I could hear Juan start to cry. I didn't know exactly what he was thinking, but my mind reverted back to every painful attack, every visit to the hospital, and every tear shed because of my HAE. I felt guilty for giving my son something that would cause him pain. No mother ever wants to cause their child pain.

JENNY: Fortunately, there are several resources and treatments available to patients with HAE. I was able to find a treatment that helps prevent my own HAE attacks. When the time comes, Sebastian will have appropriate options available as well.

JUAN: It's been great to see Jenny live her life. She's not just been an incredible mother to David and Sebastian, but she's also been teacher Jenny to our nieces during this pandemic year. For 3 days during the week, she holds classes for them, and around the holidays, they made their own gingerbread houses, and Jenny judged them on their creativity. But she also made sure to take points off if the kids ate the building supplies.

JENNY: Don't eat the gingerbread.

JUAN: Or the marshmallows.

JENNY: I mentioned at the beginning that I don't think I would have made it this far if not for Juan being in my life. His role as a husband and caregiver, along with my management plan that includes TAKHZYRO, has changed my journey with HAE. Just asking for help and allowing him to care for me was a big step in my life. And I know that he will always be there for me and our boys. Juan goes beyond just giving care; Juan gives me hope and the possibility to live life beyond my HAE.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every 2 weeks.

KELLY: Hey, my name is Kelly, and this is My Reimagine Vlog.

KELLY: Hello, my name is Kelly. I live in a small town in North Carolina, and I work as a branch manager at a bank. I've been taking TAKHZYRO for more than 2 years. The first time I went hiking was when I was in middle school–there was a trail with a bunch of stairs that led to the top of a mountain. I remember reaching the top and the amazing sight and seeing everything and thinking wow, I made it. When I woke up the next day after the hike, I had swollen legs and swollen feet. The thing is, I was diagnosed with hereditary angioedema, or HAE, when I was 7, but I never let my condition stop me from doing what I wanted to do. I especially didn't let it stop me from my love of hiking, and I kept at it through the years. Growing up with HAE was always an uphill challenge for me. Kids were harsh, and I was teased a lot.

KELLY: I remember going home one day and crying and not knowing what to do. Well, when I had swells at school, if there were things that I could hide, whether it was, you know, my feet or my legs, I just didn't talk about it or draw attention to it. But it was when I had swells at school that I couldn't hide, whether it would be my hands or my face. Luckily, I have an older brother who has always been there for me. He brought a crown over that night, a huge one, and told me to put it on my head. He told me to look down, and of course when I did, the crown slid off my head. He asked me to pick it up off the ground and wear it again—this time holding my head high. My brother said: "This crown represents your self-worth and your confidence. You should be able to walk into every room with your head held high, because you deserve respect and love. I want you to own your disease, your HAE."

KELLY: Those words have never left me, and I began to accept that fact. I had HAE, I couldn't change that fact, but I didn't have to be ashamed of it. It was still an uphill journey through the years, trying to find the right treatment for me, and I was still having attacks 1 to 3 times a week. Sometimes they were so severe that I had to go to the hospital. I knew that I wanted to find a preventive treatment because my HAE was getting in the way of how I wanted to live, so I did some research, and I found out about TAKHZYRO. I actually brought it up with my doctor.

KELLY: I was interested in TAKHZYRO because it was a once-every-2-weeks subcutaneous injection used to prevent HAE attacks in people 12 years of age and older. Of course, before making the decision to start TAKHZYRO, my doctor and I discussed several potential risks such as serious side effects, including allergic reactions, as well as more common risks, including injection site reactions, upper respiratory infections, and headaches. My doctor was very specific with me about the symptoms of an allergic reaction and told me to call or get emergency help right away if I ever experienced any of the following: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, or hives. We also discussed how TAKHZYRO could help reduce the frequency and the severity of my attacks. Sometimes on my hikes, before I reached the top, there are rest areas or viewpoints. When I first started TAKHZYRO, my doctor told me it wouldn't instantly work.

KELLY: There's this thing called "steady-state" that your doctor might talk to you about. What that means is that it takes time for TAKHZYRO to get to a constant level in the body. You have to have patience to wait for TAKHZYRO to reach that “steady-state”. About 10 weeks is around the time that my doctor said TAKHZYRO would take to build up fully in my body. Steady, state. Know that the rest areas or viewpoints are just stops along the way, and it's important to keep moving forward. Since starting TAKHZYRO, I've experienced less frequent attacks. I still experience attacks on treatment with TAKHZYRO, but the severity of my attacks decreased. I've also experienced several attack-free months since starting TAKHZYRO. Every patient's experience is different, so it's important to work with your doctor to see if TAKHZYRO would be a good option for you. I think about the first time I went hiking and where I am today. I have a whole new perspective now through my journey with HAE and TAKHZYRO. I am who I am because of the challenges I faced, and I am where I am because I kept my head up.

KELLY: Sometimes the longest hikes are the most rewarding, and TAKHZYRO has helped me reimagine my life with HAE.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every 2 weeks.

JENNY: What made me want to start TAKHZYRO^®? I love that the dosing schedule is every two weeks.

BOBBI: I was interested in trying TAKHZYRO because I heard that it could lessen the frequency of my attacks and also the severity of my attacks, and that was something that meant a lot to me.

KELLY: I like the fact that most people were able to inject within a minute or less.

LEXI: I was, you know, trying to find any treatment method that just allowed me to take my medicine less. I wanted a chance to just have to have fewer attacks, the opportunity to have fewer attacks, and to be able to take medicine less.

LEXI: And so, having both of those opportunities, I knew I needed to give it a try.

SEBASTIAN: What interested me about TAKHZYRO was that it was every two weeks and that it wasn't plasma-based. That was really important.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions.

NARRATOR: Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

LEXI: I was able to have a nurse come and train me on how to inject, and she came twice because I really wanted to feel comfortable with taking medicine and making sure that this was the decision that I was gonna make. And so, after she came and trained me twice, I’ve taken it ever since on my own, injecting myself.

ANDREA: The process for getting started with TAKHZYRO^® was pretty much straight through. My doctor mentioned that he wanted me to try TAKHZYRO. The next thing I heard from OnePath®.

JEANIE: So a nurse came to my house to train my son and myself. I believe she came out twice, if I can recall correctly and she just put me at ease. She put us at ease. She was really nice and just explained how to do it. We included my daughter into the process because she’s been through all of this with us and we did it together as a family. I did it first but she showed us, and she made sure that we were comfortable with what we were doing before.

KELLY: After getting my prescription for TAKHZYRO, I worked with my OnePath Patient Support Manager to help access my medication. She actually set up a home health nurse to come out to teach me how to administer the injection.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions.

NARRATOR: Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088.

NARRATOR: TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

NARRATOR: TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. TAKHZYRO may cause serious side effects, including allergic reactions. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

JACK: The first time I heard about TAKHZYRO was in my doctor’s office and it had just been released, that day, by the FDA. It was a big surprise to me because I was having a lot of attacks and I wanted some sort of preventative treatment and to find out that that was an option for me was great.

SORAYA: The first time I heard about TAKHZYRO, I heard some of my friends that live with HAE, they are patients too, and they were sharing their experiences.

BOB: So when I realized that it was important for me to start talking to my doctor about a preventative measure for my treatment, it was a conversation that we had in the past, but when he told me about TAKHZYRO, I was very involved with him and we stayed in constant dialogue of having a conversation with each other and making sure that it was the right time and that this was the right treatment for me.

ANDREA: My doctor made me realize it was time to talk to him about looking into TAKHZYRO.

BOBBI: One of the biggest things that we talked about was the hopes that it would lessen my frequency and the severity of my attacks.

SEBASTIAN: I heard about TAKHZYRO from my doctor. She informed me about the clinical trials of the medication and we followed those trials, and once it got approved in 2018 I reached out to her and I asked if I can get on that and that’s how I started.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

JASON: The best thing about being a caregiver is informing other people and other caregivers and telling your story to them to help them possibly relieve some stress and worrying in their lives.

JUAN: The best thing about being a caregiver is being able to advocate for your loved one and being able to make sure that they get the care that they need, and also being able to educate others around you in the community about HAE and how to manage the condition.

HEATHER: The best thing about being a caregiver, to me, is that you have somebody's back.

HEATHER: You're actually helping making somebody else's life better and that they have somebody to lean on, and they're not alone. You know that, you know, I've got you. I've got you. We're going to do this together. We're going to stay organized. We're going to stay focused, and you're going to get through this.

NARRATOR: TAKHZYRO^® (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

NARRATOR: TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist.

NARRATOR: You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

BOBBI: For other caregivers dealing with HAE, I think the biggest thing you could do is just be supportive and try to understand even if you don't truly understand what that person is going through. But just be there, and love them through it.

JASON: My advice to a new caregiver is to ask a lot of questions, get a lot of answers, and don't be scared to ask questions. There's a lot of people out there that can help, have answers, that they have gone through in their life. It may help them out.

PAM: I would tell caregivers first of all, if you don't have HAE, is to find out about it, to-to know what's going on, and what things need to be done because sometimes those attacks can be an emergency or a life-threatening situation. So, you need to be prepared about what needs to happen for the person who is having the attack. And then I think it's to be sensitive to what's going on with them, to find out or look for clues as to when they might be having attacks coming on, and they may not even recognize it themselves.

JUAN: What I would like say to other caregivers is don't lose hope. There is support out there. There is help out there, and there's a community of people that have gone through the same exact situation that you are in, and there are people that you can talk to.

NARRATOR: TAKHZYRO^® (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

NARRATOR: TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives. The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist.

NARRATOR: You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed. Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

KYLE: When I got first diagnosed with HAE, I can bring myself back to that exact day. It was Halloween and my face is swollen up. I felt like a monster. And I was the only one that couldn’t take my mask off. I was searching for an answer, and I finally found it. Yes, this sounds weird. It felt like I was punched in the gut, and my world was crumbling down around me. But since then, I’ve grown stronger. HAE lives with me, and I don’t live with it. I don’t let it control me, and it’s an amazing experience to come along to where I’m at now.

NINA: My journey of getting diagnosed with HAE was long and difficult. I was the first person in the family to actually be diagnosed, and I went through every physician and every specialty that was available to find out what was wrong with me. And I had been told, everything from it’s all in your head and it’s-you’re fine to there’s something wrong but we don’t know what it is, we don’t know what to do for it, and we don’t know how to help you.

NINA: So it was really, really quite difficult, um, not having a family history on paper or anybody who had plowed the road, so to speak, before me. I was doing it all on my own. And I almost gave up several times, but then I thought, well, if I don’t do it for my family who will? I’ve got children and grandchildren, and I don’t want them to have to go through the entire path that I did because I only got diagnosed when I was 50 years old. So I had many, many, many years before I was diagnosed.

PAM: Getting diagnosed with HAE, for me, took years. I spent more than a decade probably in the emergency room with uncontrollable vomiting and excruciating pain and really no answers as to what was wrong. And it wasn’t until I took one of my daughters in because she was having asthma and the doctor saw that my hand was swollen, and he says what’s going on? I’m sure he was concerned that I was having some kind of allergic reaction. And I said, I don’t know, it’s just swollen and it’s really not going down. And he took a look at it and said I think you may have hereditary angioedema.

PAM: I said, what’s that? What can you do for it? And at that point, there really was nothing you could do for it. So I just lived my life without any options and really answers for a long time. And then, we started making progress and seeing medicines become available. But it was years and years, more than a decade before I was able to get an answer as to what was going on.

NARRATOR: TAKHZYRO^® (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

JENNY: I see a hopeful future for people with HAE, both with preventative treatment and acute treatment.

NINA: I can’t wait to see how the newer generation is going to do with the treatment that’s available now. They will have a very, very different life than we did.

KELLY: I feel hopeful for the future for HAE patients. I think that we’re on a positive note and it’s——we only have one way to go, and that’s up.

JUAN: I see a hopeful future for people with HAE now that we have different options for treatment, both acute and prophylactic.

SCOTT: I see the future as being much brighter with technological developments in medication and science. I think we’ve come a long way from where we were before. It’s much easier to connect with people and find out about advancements in it and to meet with other people that have it, and really learn from them as well.

PAM: I see the future of HAE at this point in time as one of——not one of the——as the brightest I’ve ever seen with the most promise because we have a lot of options. We have a lot of information, and we’ve got a very proactive group that works on continuing to make things better for us.

PAM: So as far as I’m concerned, the future’s never been better for those of us with HAE.

NARRATOR: TAKHZYRO^® (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

LEXI: HAE Day, for me, means an opportunity to just reflect on where I’ve come from and where I’m headed with HAE, reflecting on my family who also has the condition, and where we've been, and you know, again, where we're headed as a family. And then the community. I mean, there are people who are just advocating for patients every single day but that one day to be able to just pause and be thankful for the opportunity to have a day for a condition that is, was seemingly invisible for a long time is huge, and it’s so impactful.

BOB: It is May 16th, but every day for me and my family is HAE Day. Having a treatment plan currently that works for me and, my lifestyle, I celebrate everyday as HAE day.

KEMMI: Well, knowing that HAE has a dedicated day is an opportunity to help share information with my friends and my family who might not understand it, who’ve been alongside me in this journey of before I was diagnosed and being concerned about what was wrong. And now, it’s just a chance for them to get involved and ask questions and to learn themselves and to be a part of this alongside me.

MARIE: It’s hard to believe that so many people have never heard of it. I know it’s a very rare disease but I feel good that I’m making them aware that this is out there for them.

KYLE: We still come together and we celebrate and raise awareness so everybody can be aware and enjoy the community that we have and the network that we have.

NARRATOR: TAKHZYRO^® (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.

KYLE: I’ve learned that we’re all family. No matter where we come from, no matter what lifestyle we have, we’re all a huge family.

MARSHA: I’ve learned a lot from other HAE patients, and the main thing I’ve learned is how strong they are, and that in turn has revealed to me that I’m strong, too. And I never thought of myself as a strong person, but now I can see that to have survived what I’ve been through does make me a strong person. And seeing how they conquer the issues in their lives, it really gives me strength to go on.

BOB: So, one of the things that I’ve learned from other people that also have HAE is that we’re, we are a resilient group of people. We’ve been knocked down, we get back up, and we’ve got to take the advice of others that have walked in our shoes.

KEMMI: The HAE community of patients is a relatively small one, so we communicate with one another a lot. The biggest thing that I’ve learned is I’m not alone. I have a community of support that has experienced the things that I’ve been through, whether it had been misdiagnosis or delays in diagnosis. We discuss future treatments and possibilities. And it has meant a lot to me to have that community support and to be able to offer support to others as well.

SCOTT: I think the most important thing I’ve learned from other patients with HAE is you’re not alone. Especially with rare diseases, it’s easy to get caught in that cycle of thinking I’m the only one or I’m the only one that can be affected, and it doesn’t matter to anybody else. But there’s really a lot of people it affects including people that aren’t patients. And it’s important to remember that because they can help you.

SEDONA: The HAE community has taught me just to stay positive through the good times and bad. And they’re always there for you. And my boyfriend has HAE also, and he has taught me to be more proactive with my health and he’s helped me a lot and I’ve helped him a lot through it. And we’ve grown together as patients and learned how to take care of ourselves to the best of our ability.

NARRATOR: TAKHZYRO (lanadelumab) is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age. TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, and/or hives.

NARRATOR: The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache. These are not all the possible side effects of TAKHZYRO. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-1088. TAKHZYRO has not been studied in pregnant or breastfeeding women. Talk to your healthcare provider about the risk of taking TAKHZYRO if you are pregnant, plan to be pregnant, are breastfeeding, or plan to breastfeed.

NARRATOR: Talk to your healthcare provider about TAKHZYRO, the only preventive HAE treatment you take as a subcutaneous injection just once every two weeks.