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TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

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TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

STAY ON TRACK
WITH TAKHZYRO

Tips for staying on top of your treatment

No matter where you are in your hereditary angioedema (HAE) and TAKHZYRO journey, it's important to make sure to take TAKHZYRO exactly as prescribed. We have the info, tools, and inspiration to help.

Start by telling us which best describes you:

Sebastian, a TAKHZYRO® (lanadelumab-flyo) patient, is building a playhouse with his son.
Sebastian

Individuals featured are TAKHZYRO patients as
of 2022 and are sharing their own experiences.
Individual experiences may vary.

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TAKHZYRO gives you freedom from daily dosing

1

MINUTE TO
SELF-INJECT
for most people in the
clinical trial

2

WEEKS
BETWEEN DOSES

3

CHOICES FOR
INJECTION SITE
stomach, thigh or upper arm

The recommended dose is 300 mg every 2 weeks. It takes about 6 doses of TAKHZYRO for the amount of medication to become constant in your body. If you experience zero attacks for more than 6 months, your doctor may consider prescribing TAKHZYRO 300 mg every 4 weeks.

Before starting treatment with TAKHZYRO, you will receive training to ensure you know how to administer your therapy. Do not attempt to take TAKHZYRO without first being trained by a healthcare provider.

Make a commitment to yourself and to TAKHZYRO

Calendar icon. TAKHZYRO® injection is taken every two weeks.

Give TAKHZYRO 2.5 months to reach steady state

With your first dose of TAKHZYRO, the medicine will start to build up in your body. Over the course of your first 6 doses, TAKHZYRO will reach a constant level—also known as "steady state." Once you get there, it’s important to keep taking TAKHZYRO exactly as prescribed to help maintain steady state.

The clinical study that lasted 6.5-months included 125 people with HAE aged 12 years and older.

Graph indicating the steady state with TAKHZYRO occurs after approximately 70 days. STEADY STATE
(about 70 days)
dose 1 dose 2 dose 3 dose 4 dose 5 dose 6
month
2.5
dose 7
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Take each dose as prescribed

TAKHZYRO continues to work as you take it, so it is important to take each dose as prescribed by your doctor. Remember also to avoid missing or skipping doses.

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Breakthrough attacks
It's possible to experience breakthrough attacks while taking TAKHZYRO. Some people may experience them more frequently in the first few months of treatment.

Always keep your on-demand treatment nearby in case you have a breakthrough attack.

If you do experience a breakthrough attack, don't get discouraged. Let your doctor know, and continue to take TAKHZYRO as prescribed.

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Stay the course
Over time, you may notice your attacks are less severe or that you’re using your on-demand treatment less. These are signs that TAKHZYRO is working.

  • The goal was to evaluate the efficacy and safety of TAKHZYRO
  • People taking TAKHZYRO 300 mg every 2 weeks saw a significant reduction in the number of monthly attacks by 87% on average compared with placebo
  • They also had an average of 83% fewer moderate or severe attacks and 87% fewer attacks requiring on-demand treatment compared with placebo
  • In a later analysis of the 6.5-month clinical study, after patients received their sixth dose of TAKHZYRO, 77% had zero attacks for the last 4 months of the study, compared to 3% of those taking placebo
    • While supportive of the main findings, the results above were not the primary focus of the clinical study. It was not designed to measure the percentage of people who had zero attacks after 2.5 months of treatment through the end of the study

In the same study, 44% of people had zero attacks for the entire 6.5 months, compared with 2% of people taking placebo.

Image of Jenny.
I continue to take TAKHZYRO as prescribed by my doctor. It’s helped decrease my attack frequency and severity.
Jenny Real TAKHZYRO patient

Need some help remembering to take TAKHZYRO?

Set up text reminders

Have you been taking TAKHZYRO for a while? We've got more resources to help you stay the course.

Get Resources

New to TAKHZYRO? We've got more resources to help you start right and stay the course.

Get Resources

A few ideas for staying on track

If you haven't already, set up a routine to help you remember your dosing schedule. Here are some tips:

Get alerts or reminders.
Create a calendar event on your phone or computer with a notification alert that repeats every other week.

Cell phone icon.

Sign up for the TAKHZYRO Text Reminder Program. Every other week, you’ll get a text message the day before and the day of your scheduled dose. Start here or text SIGNUP (o RECORDAR en español) to 36395 to get started.*

Family icon.

Ask your loved ones to help. Reach out to a family member or friend to remind you when it’s time to take your TAKHZYRO.

Calendar icon. TAKHZYRO® injection is taken every two weeks.

Choose a dosing day. Think of something easy for your schedule and easy to remember, like "TAKHZYRO Tuesday."

*Message and data rates may apply. Average of 3 messages per month. Text HELP to 36395 for more information, or text STOP to 36395 to end text reminders. View our terms and conditions at engagedrx.com/tak

Want more? Check out real patients' tips and tricks for remembering to take TAKHZYRO.

WATCH VIDEO

Get ready for your next doctor check-in

Checking on your progress is key to success— you've been tracking those goals so you and your doctor can see just how far you've come.

Here are some discussion points for your next doctor appointment:

  • Your HAE attacks: What are they like now compared to before you started taking TAKHZYRO?
  • Triggers: What things do you notice trigger your attacks (stress, exhaustion, hormonal fluctuations, physical pressure)?
  • On-demand medication: How often do you use it now that you're taking TAKHZYRO?

Be sure to journal your progress. Have you been using the Journey Journal? Bring it along and share the details with your doctor.

Since your needs might change over time, the 2020 US Hereditary Angioedema Association (HAEA) guidelines recommends you take into account the following as you create or revisit your plan:

  • Any other health issues you may have
  • The advantages of keeping a symptom and treatment tracker you can review with your doctor

Use this helpful Treatment Goals brochure to guide your conversation with your doctor.

Recently started taking TAKHZYRO? We've got more resources to help you stay the course.

Get Resources

Need some help remembering to take TAKHZYRO?

Set up text reminders

Have you been taking TAKHZYRO for a while? We've got more resources to help you stay the course.

Get Resources

Remember why you started taking TAKHZYRO

Your doctor prescribed TAKHZYRO to help you reduce the frequency and severity of your HAE attacks. HAE attacks can be unpredictable, debilitating, and even life-threatening. It's important to stick with your HAE preventive treatment plan. So continue taking TAKHZYRO as prescribed.

Need some help remembering to take TAKHZYRO?

Set up text reminders

Image of Kelly.
I stay on treatment because I remember what my HAE was like before preventive treatment. I do not want to go back there.
Kelly Real TAKHZYRO patient

2,500 people have been prescribed TAKHZYRO—just like you*

You’re one of a growing group of people who recognize the importance of having a preventive treatment as part of their HAE management plan. But even when you've been on treatment as long as you have, there's always more to learn. If you haven't already, sign up for emails to hear the latest from TAKHZYRO, including stories from other people living with HAE.

SIGN UP

*Based on third-party specialty pharmacy data

Need some help remembering to take TAKHZYRO?

Set up text reminders

Have you been taking TAKHZYRO for a while? We've got more resources to help you stay the course.

Get Resources

When it comes to staying on track, they've got great advice

Take it from people who know what it’s like: Real TAKHZYRO patients share their tips for getting off to the right start and staying on top of TAKHZYRO treatment.

Image of Dylan.
The first level to staying on track is to think ahead. I make sure that I have my medication in the fridge, and when it's time for me to inject, I take it out 15 minutes before I need to inject to ensure it's at the proper temperature.
Dylan Real TAKHZYRO patient
Image of Juan.
I would encourage anyone who is beginning treatment with TAKHZYRO to talk to their doctor about what to expect when they first start and how long it will take for TAKHZYRO to get to a constant level in the body.
Juan Real TAKHZYRO patient
Image of Jenny.
How do I remember to take TAKHZYRO? I use my calendar app, and I set the event to occur every two weeks.
Jenny Real TAKHZYRO patient
Image of Kemmi.
I get a text alert the day before so I know that I’m ready and then another text the day of.
Kemmi Real TAKHZYRO patient

Need more inspiration?

Watch patient stories

Get answers to common questions about staying on track with TAKHZYRO

While we recommend you ask your healthcare team any treatment questions you have, here are some frequently asked questions and answers you may find helpful.

How long does it take for TAKHZYRO to work?

It takes about 10 weeks for TAKHZYRO to build up in your body. It's possible to experience breakthrough attacks while taking TAKHZYRO. Some people may experience them more frequently in the first few months of treatment. Find out more about how TAKHZYRO works.

What if I miss a dose of TAKHZYRO?

If you miss a dose of TAKHZYRO, you should call your doctor to find out what to do. If you need help remembering to take your TAKHZYRO, try these tips:

  • Sign up for TAKHZYRO dosing reminders, including texts and calendar alerts.
  • Ask a friend or family member to help you remember.
  • Create a unique way to remember dosing day, like “TAKHZYRO Tuesday.”

What can I expect from treatment with TAKHZYRO?

When you take TAKHZYRO exactly as prescribed by your doctor, over time you may notice:

  • You have fewer HAE attacks, perhaps even zero attacks for periods of time
  • The HAE attacks you have are less severe
  • You use your on-demand treatment less often

Check out these study results to learn more about what you may expect from treatment with TAKHZYRO. TAKHZYRO was studied in a 6.5-month and a 2.5-year clinical study.

What are the possible side effects when taking TAKHZYRO?

TAKHZYRO may cause serious side effects, including allergic reactions. Call your healthcare provider or get emergency help right away if you experience any of the following symptoms: wheezing, difficulty breathing, chest tightness, fast heartbeat, faintness, rash, hives.

The most common side effects seen with TAKHZYRO were injection site reactions (pain, redness, and bruising), upper respiratory infection, and headache.

Check out the safety results from the 6.5-month and 2.5-year clinical studies.

Should I keep taking TAKHZYRO if I haven’t had an HAE attack in a while?

Yes, you should keep taking TAKHZYRO as prescribed. Over time, you may notice a decrease in the severity of your HAE attacks. You might even find that your HAE attacks happen less often or you are using your on-demand treatment less. These are signs that TAKHZYRO is working. But at any time, HAE attacks could start to happen more regularly, and in places that are more life-threatening (like the mouth and throat). That’s why it’s so important to keep taking TAKHZYRO as prescribed to help prevent attacks.

How do I travel with TAKHZYRO?

Traveling with TAKHZYRO just takes a little preparation. The first step is to contact your doctor and OnePath® Patient Support Manager about a month before your trip so they can help you coordinate supplies and other important details. As for packing, make sure you carry your medications and supplies with you at all times. Do not pack them in checked luggage. Download this brochure for more important information and tips on traveling with TAKHZYRO.

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Still have questions?

See what real patients taking TAKHZYRO have to say on common topics.

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CONTACT ONEPATH
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OnePath® Product Support is here for you

You'll get personalized support while you're taking TAKHZYRO. You'll have a dedicated OnePath Support Manager (PSM) to help you through it all. No matter where you are in your journey, your PSM can provide materials to help you learn more about HAE or your treatment with TAKHZYRO.

Your PSM is also there to help you—with routine check-ins, insurance updates, or making sure your TAKHZYRO is shipped to the right place. Call 1–866–888–0660, Monday through Friday, 8:30 AM to 8:00 PM ET.