TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

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TAKHZYRO is a prescription medicine used to prevent attacks of hereditary angioedema (HAE) in people 12 years of age and older. It is not known if TAKHZYRO is safe and effective in children under 12 years of age.

What is HAE?

Hereditary angioedema (HAE)
is a rare genetic disease

HAE can cause repeated attacks of swelling that can be painful and disabling. HAE is called "hereditary" because it usually runs in families. So, what causes HAE?

Typically, people with HAE are either missing an important protein in their blood called C1-inhibitor, or it doesn’t work the way it should. This can cause another protein, kallikrein, to become overactive. This increase in kallikrein activity results in too much bradykinin, the substance that causes HAE attacks.

TAKHZYRO decreases plasma kallikrein activity. See how it works here.

Lexi, a real TAKHZYRO® (lanadelumab-flyo) patient, on a sofa.
Lexi

Understanding HAE Type I and II

Most people with HAE (about 85%) have HAE Type I. Some patients with HAE (about 15%) have HAE Type II. Doctors need a blood test to show whether a patient has HAE Type I or Type II because they can look very similar to one another. They both cause swelling attacks in different locations throughout the body, and both types occur because of a genetic mutation.

Type I

  • Low level of C1-INH
  • C1-INH functions normally
  • Most common (~85% of people with HAE)

Type II

  • Normal level of C1-INH
  • C1-INH doesn't function normally
  • Less common (~15% of people with HAE)

Can HAE be misdiagnosed?

Because HAE symptoms can look very similar to the symptoms of other, more common conditions, it can be easy to misdiagnose. In a 2010 survey of 313 people with HAE, up to 65% of the participants had been misdiagnosed with another condition prior to receiving their HAE diagnosis:

  • Most commonly, skin attacks were mistaken for other skin conditions, like contact dermatitis, which can cause the skin to become irritated and swollen
  • Abdominal attacks were also confused with appendicitis or irritable bowel syndrome

What can getting misdiagnosed with another condition mean?

  • It can take longer to get an accurate HAE diagnosis
  • People who are undiagnosed are at greater risk of receiving the wrong treatment
  • In an emergency situation, like an HAE attack affecting the airway, getting the wrong treatment has the potential to be life-threatening
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TAKHZYRO was studied to see if it could help prevent HAE attacks.

See the study

Learn about HAE symptoms and attack triggers.

More HAE info